Goals before the break from Leonardo Spinazzola and Rrahmani delivered a win for Napoli at the Stadio Olimpico in a fixture overshadowed by three dismissals.
The win pushes Conte's side to just one point behind of Serie A leaders Milan, who won on Friday. Inter occupy third place but have a chance to go back to the summit with a victory in their evening fixture.
Despite missing a number of key personnel, Napoli controlled the game with measured build-up play. The opener came when Politano's delivery was drilled home by Spinazzola at the far post.
The advantage was extended in the 32nd minute as the defender guided a header from a Politano free-kick into the bottom corner. Napoli came close to a third shortly after when Elmas watched his effort rattle against the woodwork.
The second half saw further worry for the visitors when a player was forced off. This incident sparked a short altercation, leading to bookings for a Napoli defender and Lazio's Noslin—who then received a second yellow for a challenge.
"I must congratulate the lads, performing with such a high standard of technical ability and intensity without letting Lazio have control is difficult," stated the winning head coach. "We played at a exceptional level of quality."
Tempers flared again late on as two opponents were embroiled in a fierce confrontation, prompting the manager to step in. The two players were shown red cards for their part in the clash.
In Spain's La Liga, the Andalusian side endured a heavy loss at home to lowly Levante. The visitors established a lead with a fine team goal before scoring two further goals in the second period to seal a comprehensive win.
Meanwhile, Los Blancos host major must-win when they welcome Betis, after their arch-rivals increased their lead at the top. Later on other game, Atleti make the journey to face La Real.
Turning to Ligue 1, a landmark capital derby takes place as Paris FC visit powerhouses Paris Saint-Germain. The fixture marks the inaugural top-flight meeting between the neighbors in over 36 years, adding significant spice to the occasion.
